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KMID : 0043319990220030317
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Archives of Pharmacal Research
1999 Volume.22 No. 3 p.317 ~ p.319
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In Vitro Anticomplementary Activity of Hederagenin Saponins Isolated from Roots of Dipsacus asper
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Oh Sei-Ryang
Jung Keun-Young
Son Kun-Ho
Park Si-Hyung
Lee Im-Seon
Ahn Kyung-Seop
Lee Hyeong-Kyu
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Abstract
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Anticomplementary activity of hederagenin and related saponins isolated from Dipsacus asper was investigated in vitro. HN saponin F (3) was most potent with value of followed by 3-O- hederagenin -D-glucopyrano side (8), hederagenin (5), dipsacus saponin A (4), and hederagenin (1) on the classical pathway (CP) of complement system, while the saponins 3-5 did not show the inhibition of hemolysis and rather increase the hemolysis on the alternative pathway (AP). However, all of C-3 monodesmosides [prosapogenin CP (2), dipsacus saponin B (6), and dipsacus saponin C (7)] evoked hemolysis directly on the erythrocytes.
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KEYWORD
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Anticomplementary activity, Hederagenin, Hederagenin saponins, Dipsacus asper
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